Support for projects focusing on clinical/biological heterogeneity among IBD patients living with chronic pain and the underlying cellular/molecular mechanisms.
The Crohn’s & Colitis Foundation, based in the United States, provides a range of domestic and international funding to support research relevant to inflammatory bowel disease (IBD), Crohn’s disease and ulcerative colitis.
The Foundation’s Chronic Abdominal Pain in IBD Request for Proposals (RFP) seeks to fund projects focusing on characterising the clinical and biological heterogeneity among IBD patients living with chronic pain, and on the underlying cellular and molecular mechanisms. This is a critical unmet need as many IBD patients experience chronic abdominal pain, which can persist even if inflammation is under control.
Current treatments for pain management in IBD are inadequate. The development of new treatment modalities is a pressing priority, but progress has been limited by insufficient understanding of the biological causes of chronic abdominal pain in IBD.
Successful proposals must incorporate both of the following objectives:
- Characterisation of the phenotypic and endotypic heterogeneity of IBD patients with chronic abdominal pain
- Understanding mechanisms driving chronic pain in IBD
Studies must integrate both patient-based profiling and experimental model-based mechanistic studies.